Clinical study with bleomycin
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منابع مشابه
Phase I clinical and pharmacological study of iododeoxyuridine and bleomycin in patients with advanced cancer.
Studies previously performed in our laboratory demonstrated synergistic cytotoxicity and DNA strand break formation in human tumor cells following exposure to a combination of bromodeoxyuridine and bleomycin. Synergy was evident when bromodeoxyuridine was administered prior to or simultaneously with bleomycin and occurred over a wide range of concentration ratios. We therefore undertook a phase...
متن کاملPhase I Clinical and Pharmacological Study of lododeoxyuridine and Bleomycin in Patients with Advanced Cancer1
Studies previously performed in our laboratory demonstrated synergistic cytotoxicity and DMA strand break formation in human tumor cells following exposure to a combination of bromodeoxyuridine and bleomycin. Synergy was evident when bromodeoxyuridine was administered prior to or simultaneously with bleomycin and occurred over a wide range of concentration ratios. We therefore undertook a phase...
متن کاملElectrochemotherapy with bleomycin - a resume of published clinical trials
Introduction Electroporation is characteristed by the use of short, high voltage pulses which transiently permeabilize the cell membrane. As electroporation can be used to introduce various molecules directly into the cell cytosol, an obvious use has been to introduce chemotherapeutic drugs directly into cancer cells (electrochemotherapy). Many chemotherapeutic drugs are lipophilic and enter ce...
متن کاملUltrastructural study of pulmonary bleomycin toxicity.
Ultrastructural manifestations of bleomycin A2 toxicity in the human lung were studied in three patients. In addition to the appearance of nucleolar fibrillar centers, an increase in membranous, beaded, and granular nuclear bodies was found in nuclei of type 1, type 2 alveolar epithelial cells, and interstitial fibroblasts in all treated patients. Few such nuclear bodies were found in specimens...
متن کاملInteraction of bleomycin with DNA
It has been shown previously that two structural domains of bleomycin mediate the interaction of the antitumor antibiotic with DNA. At least three lines of evidence indicate that the metal binding domain is the predominant partner, and is responsible for the sequence selectivity of DNA cleavage observed for Fe(II)*BLM. The bithiazole + C-terminus has been shown previously to bind to DNA, but no...
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ژورنال
عنوان ژورنال: Cancer
سال: 1971
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(1971)28:5<1142::aid-cncr2820280509>3.0.co;2-a